Publikationen zur Systembiologie

A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.

Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis.

Probability of self-renewal: Assumptions and limitations. A commentary.

Mathematische Modelle in der Haematologie.

The kinetics of hematopoietic stem cells during and after hypoxia - A model analysis.

The kinetics of granulopoiesis in long term mouse bone marrow culture. Part I.

The kinetics of granulopoiesis in long term mouse bone marrow culture. Part II.

The kinetics of granulopoiesis in long term mouse bone marrow culture. Part II.

Mathematical Modeling of Cell Proliferation

Analysis of the changes in the proportion of clustered labelled cells in epidermis.

Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt.

A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy.

Epidermal cell proliferation I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis.

Epidermal cell proliferation II. A comprehensive mathematical model of cell proliferation and migration in the basal layer predicts some unusual properties of epidermal stem cells.

Epidermal cell kinetics in pig skin.

A concept of hemopoietic regulation and its biomathematical realisation.

Scoring mitotic activity in the crypts of the murine small intestine.

Interstinal crypt proliferation. II. Computer modeling of mitotic index data provides further evidence for lateral and vertical cell migration in the absence of mitotic activity.

Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages.

Hemopoiesis during thiamphenicol treatment. II. A theoretical analysis shows consistency of new new data with a previously hypothesized model of stem cell regulation.

A mathematical model of erythropoiesis in mice and rats.
Part 1. Structure of the model.

A mathematical model of erythropoiesis in mice and rats.
Part 2. Stimulated erythropoiesis.

A mathematical model of erythropoiesis in mice and rats.
Part 3. Suppressed erythropoiesis.

A mathematical model of erythropoiesis in mice and rats.
Part 4. Differences between bone marrow and spleen.

Migration of stem cells and progenitors between marrow and spleen following a thiamphenicol treatment of mice.

A mathematical model of erythropoiesis suggests an altered plasma volume control as cause for anemia in aged mice.

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.

Synchrony of marrow maturation as origin of cyclic hemopoiesis.

Age-related changes in the cell kinetics of rat epidermis

Differential effects of rekombinant human colony stimulating factor (rh G-CSF) on stem cells in marrow, spleen and peripheral blood in mice.

A stochastic branching model with formation of subunits applied to the growth of intestinal crypts.

Hematotoxic effects of benzene analyzed by mathematical modeling.

A mathematical approach to benzo[a]pyrene-induced hematotoxicity.

A model of the control of cellular regeneration in the intestinal crypt after perturbation, based solely on local stem cell regulation.

Somatic mutation, monoclonality and models of stem cell organization in the intestinal crypt.

The differentiation and lineage development of goblet cells in the murine small intestinal crypt: experimental and modelling studies.

Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesis

Reduced variance of bone-marrow transit time of granulopoiesis - a possible pathomechanism of human cyclic neutropenia.

The crypt cycle in mouse small intestinal epthelium.

Mutual inhibition of murine erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor and stem cell factor adminstration: In vivo interactions and dose response surfaces.

Effects of Continuous Stem Cell Factor Administration on Normal and Erythropoietin- Stimulated Murine Hemopoiesis. Experimental Results and Model Analysis.

Hematoxicity by prolonged etoposide adminstration to mice can be prevented by simultaneous growth factor therapy.

The kinetics of murine hemopoietic stem cells in vivo in response to prolonged increased mature blood cell production, induced by granulocyte colony-stimulating factor.

In vivo effects of interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis.

Model analysis of the contrasting effects of GM-CSF and G-CSF treatment on peripheral blood neutrophils observed in three patients with childhood-onset cyclic neutropenia.

Rationale for dose escalation of first line conventional chemotherapy in advanced Hodgkin's disease.

A cure model with time-changing risk factor: An application to the analysis of secondary leukemia.

Interactions of Erythropoietin, Granulocyte Colony-Stimulating Factor, Stem Cell Factor, and Interleukin-11 on Murine Hematopoiesis During Simultaneous Administration

A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.

Regression with bounted outcome score: Evaluation of power by bootstrap and simulation in a chronic myelogenous leukemia clinical trial

Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease.

Endogenous thrombopoietin serum levels during multicycle chemotherapy

Proliferation in murine epidermis after minor mechanical stimulation - Part 1: Sustained increase in keranocyte production and migration.

Proliferation in murine epidermis after minor mechanical stimulation - Part 2: Alterations in keranocyte cell cycle fluxes.

Individual-based models to growth and folding in lne-layered tissues: Intestinal cryps and early development

Cell migration and organization in the intestinal crypt using a lattice-free model

Modelling of chemotherapy: The effective dose approach

Tissue Stem Cells: definition, plasticity, heterogeneity, self organization and models - a conceptual approach.

A Novel Dynamic Model of Hematopoietic Stem Cell Organization Based on the Concept of Within-Tissue Plasticity

Cell kinetic studies in the murine ventral tongue epithelium: thymidine metabolism studies and circadian rhythm determination

Modelling the effects of continuous irradiation on murine haematopoiesis.

Quantitative tissue stem cell modeling

Interactions in Oligonucleotide Hybrid Duplexes on Microarrays

Sensitivity of Microarray Oligonucleotide Probes: Variability and the Effect of Base Composition

A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy

Conceptual models to understand tissue stem cell organization

Modelling Human Granulopoiesis under Polychemotherapy with G-CSF Support

Micro Array Based Gene Expression Analysis using Parametric Multivariate Tests per Gene - A Generalized Application of Multiple Procedures with Data-driven Order of Hypotheses

Theoretical concepts of tissue stem cell organization

Modeling the Effect of Deregulated Proliferation and Apoptosis on the Growth Dynamics of Epithelial Cell Populations in Vitro

Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization

Increased power of microarray analysis by use of an algorithm based on a multivariate procedure

Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia

Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1

Quantitative stem cell biology - Computational studies in the hematopoietic system