Biometry, Bioinformatics and Systems Biology
The task of biometricy goes substantially beyond the formal statistical analysis of data and studies.
Biometry is also concerned with the:
- characteristics of bio-medically measured variables
- experimental design of how medical-biological data is derived
- synthesis and critical evaluation of existing medical evidence
Therefore, it can contribute, by mathematical-statistical modelling of these processes, to substantial gains in the knowledge and understanding of complex interactions.
The IMISE's bioinformatics and systems biology research focuses on the following fields interests are divided into the following project groups:
- Models of Blood Formation
The goal of this project group is to achieve by biomathematical models a comprehensive quantitative understanding of the dynamics of hematopoietic cell population, proliferation and differentiation. On the basis of clinical and experimental data, disorders of the blood formation are examined and predicted.
- Methods of the Evidence Synthesis and Model-based Study Planning
To help understand the mechanism of disease and to plan new clinical studies, it is necessary to summarize already existing evidence from the literature and to simulate biometrically, the relevant aspects of the disease using mathematical models.
- Analysis of High-dimensional Microarray Data
The goal of this project group is to develop and amend statistical methods so as to allow the processing, description and modelling interpretation of high-dimensional data structures.
- Statistics and Computational Biology
- The goal of this project group is the development and application of statistical techniques in the analysis of medical and bionformatics data.
A summary of scientific activities at the University of Leipzig with regard to "Systems Biology" can be found on the web-sites of the Interdisciplinary Centre for Bioinformatics Leipzig (IZBI).