Publications in peer-reviewed journals and books on systems biology until 2006 are listet on this page. Further publications on systems biology can be found in the IMISE publication database.
1980
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LOEFFLER, M., WICHMANN,H.E.A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.Cell Tissue Kinet. 13 (1980) 543-561
Download (643 kB, Englisch)
1982
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POTTEN, C. S.; WICHMANN, H. E.; LOEFFLER, M.; DOBEK, K.; MAJOR, D.Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis.Cell Tissue Kinet. 15 (1982) 305-329 Download (1,0 MB, Englisch)
1983
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WICHMANN, H. E.; LOEFFLER, M.Probability of self-renewal: Assumptions and limitations. A commentary.Blood Cells 9 (1983) 475-483 Download (289 kB, Englisch)
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WICHMANN,H.E.; LOEFFLER, M.;HERKENRATH,P.;GERHARDTS,M.D.;WESSELBORG,C.; WULFF,H.Mathematische Modelle in der Haematologie.Klin. Wochenschrift 61 (1983) 935-940 Download (361 kB)
1984
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LOEFFLER, M.; HERKENRATH,P.; WICHMANN,H..E.; LORD,B.I.; MURPHY,M.J.The kinetics of hematopoietic stem cells during and after hypoxia - A model analysis.Blood 49 (1984) 427-439 Download (375 kB)
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REINCKE,U.; LOEFFLER, M.; WICHMANN,H..E.; HARRISON,B.The kinetics of granulopoiesis in long term mouse bone marrow culture. Part I.Int.J.Cell Cloning 2 (1984) 394-407 Download (402 kB)
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WICHMANN,H..E.; LOEFFLER, M.; REINCKE,U.The kinetics of granulopoiesis in long term mouse bone marrow culture. Part II.Int.J.Cell Cloning 2 (1984) 408-424 Download (474 kB)
1985
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Wichmann HE, Loeffler MMathematical Modeling of Cell ProliferationBoca Raton, FL, CRC, 1985 Download (26,3 MB, Englisch)
1986
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LOEFFLER, M.; POTTEN,C.S.; DITCHFIELD,A.; WICHMANN,H..E.Analysis of the changes in the proportion of clustered labelled cells in epidermis.Cell Tissue Kinet. 19 (1986) 377-389 Download (485 kB)
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LOEFFLER, M.; STEIN,R.; WICHMANN,H.E.; POTTEN,C.S.; KAUR,P.; CHWALINSKI,S.Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt.Cell Tissue Kinet 19 (1986) 627-645 Download (757 kB)
1987
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POTTEN,C.S.; LOEFFLER, M.A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy.J. Theor. Biol. 127 (1987) 381-391 Download (335 kB)
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POTTEN, C.S.; LOEFFLER, M.Epidermal cell proliferation I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis.Virchow's Archiv B 53 (1987) 279-285
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LOEFFLER, M.; POTTEN, C. S.; WICHMANN, H. E.Epidermal cell proliferation II. A comprehensive mathematical model of cell proliferation and migration in the basal layer predicts some unusual properties of epidermal stem cells.Virchow's Archiv B 53 (1987) 286-300 Download (894 kB)
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MORRIS,G.M.; REZVANI,M.; HOPEWELL,J.W.; FRANKE,H.; LOEFFLER, M.Epidermal cell kinetics in pig skin.Epithelia 1 (1987) 231-342 Download (484 kB)
1988
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WICHMANN, H.-E.; LOEFFLER, M.; SCHMITZ,S.A concept of hemopoietic regulation and its biomathematical realisation.Blood Cells 14 (1988) 411-429 Download (656 kB)
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POTTEN,C.S.; ROBERTS,S.; CHWALINSKI,S.; LOEFFLER, M.; PAULUS,U.Scoring mitotic activity in the crypts of the murine small intestine.Cell Tissue Kinet. 21 (1988) 231-246 Download (1002 kB)
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LOEFFLER, M.; POTTEN,C.S.; PAULUS,U.; GLATZER,J.; CHWALINSKI,S.Interstinal crypt proliferation. II. Computer modeling of mitotic index data provides further evidence for lateral and vertical cell migration in the absence of mitotic activity.Cell Tissue Kinet. 21 (1988) 247-258 Download (886 kB)
1989
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GORIS,H.; LOEFFLER, M.; BUNGART,B.; GORIS,H.; SCHMITZ,S.; NIJHOF,W.Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages.Exp. Hematol. 17 (1989) 957-961 Download (615 kB)
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LOEFFLER, M.; BUNGART,B.; GORIS,H.; SCHMITZ,S.; NIJHOF,W.Hemopoiesis during thiamphenicol treatment. II. A theoretical analysis shows consistency of new new data with a previously hypothesized model of stem cell regulation.Exp. Hematol. 17 (1989) 962-967 Download (924 kB)
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LOEFFLER, M.; PANTEL,K.; WULFF,H.; WICHMANN,H.E.A mathematical model of erythropoiesis in mice and rats.
Part 1. Structure of the model.Cell Tissue Kinet. 22 (1989) 13-30 Download (1,3 MB) -
WICHMANN,H.-E.; LOEFFLER, M.; PANTEL,K.; WULFF,H.A mathematical model of erythropoiesis in mice and rats.
Part 2. Stimulated erythropoiesis.Cell Tissue Kinet. 22 (1989) 31-49 Download (757 kB) -
WULFF,H.; WICHMANN,H..E.; LOEFFLER, M.; PANTEL,K.A mathematical model of erythropoiesis in mice and rats.
Part 3. Suppressed erythropoiesis.Cell Tissue Kinet. 22 (1989) 51-61 Download (910 kB)
1990
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PANTEL,K.; LOEFFLER, M.; BUNGART,B.; WICHMANN,H.E.A mathematical model of erythropoiesis in mice and rats.
Part 4. Differences between bone marrow and spleen.Cell Tissue Kinet. 23 (1990) 283-297 Download (1,2 MB) -
GORIS,H.; BUNGART,B.; LOEFFLER, M.; NIJHOF,W.Migration of stem cells and progenitors between marrow and spleen following a thiamphenicol treatment of mice.Exp. Hematol. 18 (1990) 400-407 Download (9,4 MB)
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LOEFFLER, M.; PANTEL,K.A mathematical model of erythropoiesis suggests an altered plasma volume control as cause for anemia in aged mice.Exp. Gerontology 25 (1990) 483-495 Download (676 kB)
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POTTEN,C.S.; LOEFFLER, M.Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.Development 110 (1990) 1001-1018
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SCHMITZ,S.; LOEFFLER, M.; JONES,J.B.; LANGE,R.D.; WICHMANN,H.E.Synchrony of marrow maturation as origin of cyclic hemopoiesis.Cell Tissue Kinet. 23 (1990) 425-441 Download (616 kB)
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MORRIS,G.M., VAN DEN AARDWEG,G.J.M.J., HAMLET,R., WHITEHOUSE,E., HOPEWELL,J.W., FRANKE,H., LOEFFLER, M.Age-related changes in the cell kinetics of rat epidermisCell Tissue Kinet. 23 (1990) 113-123 Download (439 kB)
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BUNGART,B.; LOEFFLER, M.; GORIS,H.; DONTJE,B.; DIEHL,V.; NIJHOF,W.Differential effects of rekombinant human colony stimulating factor (rh G-CSF) on stem cells in marrow, spleen and peripheral blood in mice.Br. J. Haematol. 76 (1990) 174-179 Download (286 kB)
1991
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LOEFFLER, M.; GROSSMANN,B.A stochastic branching model with formation of subunits applied to the growth of intestinal crypts.J. Theoretical Biol. 150 (1991) 175-191 Download (1,3 MB)
1992
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SCHEDING,S.; LOEFFLER, M.; SCHMITZ,S.; SEIDEL,H.J.; WICHMANN,H.E.Hematotoxic effects of benzene analyzed by mathematical modeling.Toxicology 72 (1992) 265-279 Download (588 kB)
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SCHEDING,S.; LOEFFLER, M.; ANSELSETTER,V.; WICHMANN,H.E.A mathematical approach to benzo[a]pyrene-induced hematotoxicity.Arch Toxicology 66 (1992) 546-550 Download (362 kB)
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PAULUS,U.; POTTEN,C.; LOEFFLER, M.A model of the control of cellular regeneration in the intestinal crypt after perturbation, based solely on local stem cell regulation.Cell Proliferation 25 (1992) 559-578 Download (969 kB)
1993
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LOEFFLER, M.; BIRKE,A.; WINTON,D.; POTTEN,C.S.Somatic mutation, monoclonality and models of stem cell organization in the intestinal crypt.J. Theoretical Biol. 160 (1993) 471 - 491 Download (1,6 MB)
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PAULUS, U.; LÖFFLER, M.; ZEIDLER,J.; OWEN,G.; POTTEN, C.S.The differentiation and lineage development of goblet cells in the murine small intestinal crypt: experimental and modelling studies.J. Cell Science 106 (1993) 473-484 Download (1,0 MB)
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NIJHOF, W.; GORIS, H.; DONTJE, B.; DRESZ, J.; LOEFFLER, M.Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesisExperimental Hematology 21 (1993) 496 - 501 Download (359 kB)
1994
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SCHMITZ, S.; FRANKE. H.; LOEFFLER, M.; WICHMANN, H.E.; DIEHL. V.Reduced variance of bone-marrow transit time of granulopoiesis - a possible pathomechanism of human cyclic neutropenia.Cell Prolif. 27 (1994) 655-667 Download (1,2 MB, Englisch)
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LI., Y.Q.; ROBERTS,S.A.; PAULUS, U.; LOEFFLER, M.; POTTEN, C.S.The crypt cycle in mouse small intestinal epthelium.Journal of Cell Science 107 (1994) 3271-3279 Download (1,4 MB, Englisch)
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DE HAAN, G.; ENGEL, CH; DONTJE, B.; NIJHOF,W.; LOEFFLER, M.Mutual inhibition of murine erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor and stem cell factor adminstration: In vivo interactions and dose response surfaces.Blood 12 Vol 84 (1994) 4157-4163 Download (810 kB, Englisch)
1995
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DE HAAN, G.; DONTJE, B.; NIJHOF,W.; LOEFFLER, M.Effects of Continuous Stem Cell Factor Administration on Normal and Erythropoietin- Stimulated Murine Hemopoiesis. Experimental Results and Model Analysis.Stem Cells (Dayt) 13 (1995) 65-76 Download (1,3 MB, Englisch)
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DE HAAN, G.; ENGEL, C.; DONTJE, B.; LOEFFLER, M.; NIJHOF, W.Hematoxicity by prolonged etoposide adminstration to mice can be prevented by simultaneous growth factor therapy.Cancer Research 55 (1995) 324-329 Download (756 kB, Englisch)
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DE HAAN, G.; DONTJE, B.; ENGEL, C.; LOEFFLER, M.; NIJHOF, W.The kinetics of murine hemopoietic stem cells in vivo in response to prolonged increased mature blood cell production, induced by granulocyte colony-stimulating factor.Blood 86: 8 (1995) 2986-2992 Download (711 kB, Englisch)
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DE HAAN, G.; DONTJE, B.; ENGEL, CH.; LOEFFLER, M.; NIJHOF, W.In vivo effects of interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis.British Journal of Hematology (1995) 90: 4, 783-790 Download (942 kB, Englisch)
1996
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SCHMITZ S., FRANKE H., LOEFFLER M., WICHMANN H.E., DIEHL V.Model analysis of the contrasting effects of GM-CSF and G-CSF treatment on peripheral blood neutrophils observed in three patients with childhood-onset cyclic neutropenia.British Journal of Hematology 95: 4 (1996) 616-625 Download (714 kB, Englisch)
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HASENCLEVER D., LOEFFLER M., Diehl V. for the German Hodgkin's Lymphoma Study GroupRationale for dose escalation of first line conventional chemotherapy in advanced Hodgkin's disease.Annals of Oncology 7: 4 (1996) 95-98 Download (445 kB, Englisch)
1998
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LOEFFLER M., TSODIKOV A.D., YAKOVLEV A.YU.A cure model with time-changing risk factor: An application to the analysis of secondary leukemia.Statistics in Medicine 17 (1998) 27-40
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ROEDER I., DE HAAN G., ENGEL C., NIJHOF W., DONTJE B., LOEFFLER M.Interactions of Erythropoietin, Granulocyte Colony-Stimulating Factor, Stem Cell Factor, and Interleukin-11 on Murine Hematopoiesis During Simultaneous AdministrationBlood 91: 9 (1998) 3222-3229 Download (1,8 MB, Englisch)
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GERIKE T.G., PAULUS U., POTTEN C.S., LOEFFLER M.A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.Cell Proliferation 31, (1998) 93-110 Download (1,5 MB, Englisch)
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TSODIKOV A.D., HASENCLEVER D., LOEFFLER M.Regression with bounted outcome score: Evaluation of power by bootstrap and simulation in a chronic myelogenous leukemia clinical trialStatistics in Medicine 17 (1998) 1909-1922 Download (1006 kB, Englisch)
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LOEFFLER M., HASENCLEVER D., DIEHL V. for the German Hodgkin's Lymphoma Study GroupModel based development of the BEACOPP regimen for advanced stage Hodgkin's disease.Annals of Oncology 9 (1998) 5: 73-78 Download (573 kB, Englisch)
1999
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ENGEL C., LOEFFLER M., FRANKE H., SCHMITZ ST.Endogenous thrombopoietin serum levels during multicycle chemotherapyBritish Journal of Haematology (1999) 105, 832-838 Download (431 kB, Englisch)
2000
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POTTEN C. S., BARTHEL D., LI Y. Q., OHLRICH R., MATTHÉ B., LOEFFLER M.Proliferation in murine epidermis after minor mechanical stimulation - Part 1: Sustained increase in keranocyte production and migration.Cell Proliferation 33, 231-246 (2000) Download (253 kB, Englisch, 16 Seiten)
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BARTHEL D., MATTHÉ B., POTTEN C. S., OWEN G., LOEFFLER M.Proliferation in murine epidermis after minor mechanical stimulation - Part 2: Alterations in keranocyte cell cycle fluxes.Cell Proliferation 33, 247-259 (2000) Download (146 kB, Englisch, 13 Seiten)
2001
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DRASDO D., LOEFFLER, M.Individual-based models to growth and folding in lne-layered tissues: Intestinal cryps and early developmentNonlinear Analysis 47 (2001) 245-256 Download (590 kB, Englisch, 12 Seiten)
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MEINEKE F.A., POTTEN C.S., LOEFFLER, M.Cell migration and organization in the intestinal crypt using a lattice-free modelCell Proliferation 34, 253-266 (2001) Download (834 kB, Englisch, 14 Seiten)
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HASENCLEVER D., BROSTEANU O., GERIKE T., LOEFFLER M.Modelling of chemotherapy: The effective dose approachAnn. Hematol. 80: B89-B94 (2001) Download (58 kB, Englisch, 6 Seiten)
2002
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LOEFFLER M., ROEDER I.Tissue Stem Cells: definition, plasticity, heterogeneity, self organization and models - a conceptual approach.Cells Tissues Organs 171 (1) 8-26 (2002) Download (354 kB, Englisch, 19 Seiten)
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ROEDER I., LOEFFLER M.A Novel Dynamic Model of Hematopoietic Stem Cell Organization Based on the Concept of Within-Tissue PlasticityExperimental Hematology 30 (8), 853-861 (2002) Download (471 kB, Englisch, 9 Seiten)
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C.S. POTTEN, D. BOOTH, N.J. CRAGG, G.L. TUDOR, J.A. O'SHEA, D. APPLETON, D. BARTHEL, T. GERIKE, F. MEINEKE, M. LOEFFLER, C. BOOTHCell kinetic studies in the murine ventral tongue epithelium: thymidine metabolism studies and circadian rhythm determinationCell Proliferation 35 (S1) 1-15 (2002) Download (319 kB, Englisch, 15 Seiten)
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LOEFFLER M.Modelling the effects of continuous irradiation on murine haematopoiesis.British Journal of Radiology (S26) 188-197 (2002) Download (477 kB, Englisch, 10 Seiten)
2003
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ROEDER I., LOEFFLER M., QUESENBERRY P.J., COLVIN G.A., LAMBERT J.F.Quantitative tissue stem cell modelingBlood 102 (3): 1143-1144 (2003) Download (85 kB, Englisch, 3 Seiten)
2004
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H. BINDER, T. KIRSTEN, I. L. HOFACKER, P. F. STADLER, M. LOEFFLERInteractions in Oligonucleotide Hybrid Duplexes on MicroarraysJ. Phys. Chem. B 108 (46) 18015 - 18025 (2004) Download (491 kB, Englisch, 11 Seiten)
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H. BINDER, T. KIRSTEN, M. LOEFFLER, P.F. STADLERSensitivity of Microarray Oligonucleotide Probes: Variability and the Effect of Base CompositionJ. Phys. Chem. B 108 (46) 18003-18014 (2004) Download (919 kB, Englisch, 12 Seiten)
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C. ENGEL, M. SCHOLZ, M. LOEFFLERA computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapyBLOOD 104 (8) 2323-2331 (2004) Download (343 kB, Englisch, 9 Seiten)
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M. LOEFFLER AND I. ROEDERConceptual models to understand tissue stem cell organizationCurrent Opinion in Hematology 11; 81-87 (2004) Download (870 kB, Englisch, 7 Seiten)
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M. SCHOLZ, C. ENGEL, M. LOEFFLERModelling Human Granulopoiesis under Polychemotherapy with G-CSF SupportJournal of Mathematical Biology 10.1007 285 - 295 (2004) Download (769 kB, Englisch, 43 Seiten)
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E.Schuster, S.Kropf, and I. RoederMicro Array Based Gene Expression Analysis using Parametric Multivariate Tests per Gene - A Generalized Application of Multiple Procedures with Data-driven Order of HypothesesBiometrical Journal 46(6): 687698 Download (200 kB, Englisch, 12 Seiten)
2005
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I. ROEDER, J. GALLE, M. LOEFFLERTheoretical concepts of tissue stem cell organizationin print (2005)
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Jörg Galle, Markus Loeffler, Dirk DrasdoModeling the Effect of Deregulated Proliferation and Apoptosis on the Growth Dynamics of Epithelial Cell Populations in VitroBiophysical Journal, 88, Pages 62-75 (2005) Download (415 kB, Englisch)
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I. Roeder, M. Kamminga, K. Braesel, B. Dontje, G. de Haan, M. LOEFFLERCompetitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organizationBlood, 15 / 2, Pages 609 - 616 (2005) Download (284 kB, Englisch, 8 Seiten)
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K. Krohn, M. Eszlinger, R. Paschke, I. Roeder, and E. SchusterIncreased power of microarray analysis by use of an algorithm based on a multivariate procedureBioinformatics 21(17): 3530-4 Download (107 kB, Englisch, 5 Seiten)
2006
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Markus Scholz, Christoph Engel, Markus LoefflerModel-based design of chemotherapeutic regimens that account for heterogeneity in leucopoeniaBritish Journal of Haematology, 132, Pages 723-735 (2006) Download (8,9 MB, Englisch)
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I. Roeder and I. GlaucheTowards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1J. Theor. Biol. (in press) Download (410 kB, Englisch)
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I. RoederQuantitative stem cell biology - Computational studies in the hematopoietic systemCurr. Opin. Hematol. 13(4):222-8 Download (178 kB, Englisch)