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INSTITUT FÜR MEDIZINISCHE INFORMATIK, STATISTIK UND EPIDEMIOLOGIE

Publications about Systems Biology

Publications in peer-reviewed journals and books on systems biology until 2006 are listet on this page. Further publications on systems biology can be found in the IMISE publication database.

1980

  • LOEFFLER, M., WICHMANN,H.E.
    A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.
    Cell Tissue Kinet. 13 (1980) 543-561

    PDF Download (643 kB, Englisch)

1982

  • POTTEN, C. S.; WICHMANN, H. E.; LOEFFLER, M.; DOBEK, K.; MAJOR, D.
    Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis.
    Cell Tissue Kinet. 15 (1982) 305-329

    PDF Download (1,0 MB, Englisch)

1983

  • WICHMANN, H. E.; LOEFFLER, M.
    Probability of self-renewal: Assumptions and limitations. A commentary.
    Blood Cells 9 (1983) 475-483

    PDF Download (289 kB, Englisch)

  • WICHMANN,H.E.; LOEFFLER, M.;HERKENRATH,P.;GERHARDTS,M.D.;WESSELBORG,C.; WULFF,H.
    Mathematische Modelle in der Haematologie.
    Klin. Wochenschrift 61 (1983) 935-940

    PDF Download (361 kB)

1984

  • LOEFFLER, M.; HERKENRATH,P.; WICHMANN,H..E.; LORD,B.I.; MURPHY,M.J.
    The kinetics of hematopoietic stem cells during and after hypoxia - A model analysis.
    Blood 49 (1984) 427-439

    PDF Download (375 kB)

  • REINCKE,U.; LOEFFLER, M.; WICHMANN,H..E.; HARRISON,B.
    The kinetics of granulopoiesis in long term mouse bone marrow culture. Part I.
    Int.J.Cell Cloning 2 (1984) 394-407

    PDF Download (402 kB)

  • WICHMANN,H..E.; LOEFFLER, M.; REINCKE,U.
    The kinetics of granulopoiesis in long term mouse bone marrow culture. Part II.
    Int.J.Cell Cloning 2 (1984) 408-424

    PDF Download (474 kB)

1985

1986

  • LOEFFLER, M.; POTTEN,C.S.; DITCHFIELD,A.; WICHMANN,H..E.
    Analysis of the changes in the proportion of clustered labelled cells in epidermis.
    Cell Tissue Kinet. 19 (1986) 377-389

    PDF Download (485 kB)

  • LOEFFLER, M.; STEIN,R.; WICHMANN,H.E.; POTTEN,C.S.; KAUR,P.; CHWALINSKI,S.
    Intestinal cell proliferation. I. A comprehensive model of steady-state proliferation in the crypt.
    Cell Tissue Kinet 19 (1986) 627-645

    PDF Download (757 kB)

1987

  • POTTEN,C.S.; LOEFFLER, M.
    A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy.
    J. Theor. Biol. 127 (1987) 381-391

    PDF Download (335 kB)

  • POTTEN, C.S.; LOEFFLER, M.
    Epidermal cell proliferation I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis.
    Virchow's Archiv B 53 (1987) 279-285
  • LOEFFLER, M.; POTTEN, C. S.; WICHMANN, H. E.
    Epidermal cell proliferation II. A comprehensive mathematical model of cell proliferation and migration in the basal layer predicts some unusual properties of epidermal stem cells.
    Virchow's Archiv B 53 (1987) 286-300

    PDF Download (894 kB)

  • MORRIS,G.M.; REZVANI,M.; HOPEWELL,J.W.; FRANKE,H.; LOEFFLER, M.
    Epidermal cell kinetics in pig skin.
    Epithelia 1 (1987) 231-342

    PDF Download (484 kB)

1988

  • WICHMANN, H.-E.; LOEFFLER, M.; SCHMITZ,S.
    A concept of hemopoietic regulation and its biomathematical realisation.
    Blood Cells 14 (1988) 411-429

    PDF Download (656 kB)

  • POTTEN,C.S.; ROBERTS,S.; CHWALINSKI,S.; LOEFFLER, M.; PAULUS,U.
    Scoring mitotic activity in the crypts of the murine small intestine.
    Cell Tissue Kinet. 21 (1988) 231-246

    PDF Download (1002 kB)

  • LOEFFLER, M.; POTTEN,C.S.; PAULUS,U.; GLATZER,J.; CHWALINSKI,S.
    Interstinal crypt proliferation. II. Computer modeling of mitotic index data provides further evidence for lateral and vertical cell migration in the absence of mitotic activity.
    Cell Tissue Kinet. 21 (1988) 247-258

    PDF Download (886 kB)

1989

  • GORIS,H.; LOEFFLER, M.; BUNGART,B.; GORIS,H.; SCHMITZ,S.; NIJHOF,W.
    Hemopoiesis during thiamphenicol treatment. I. Stimulation of stem cells during eradication of intermediate cell stages.
    Exp. Hematol. 17 (1989) 957-961

    PDF Download (615 kB)

  • LOEFFLER, M.; BUNGART,B.; GORIS,H.; SCHMITZ,S.; NIJHOF,W.
    Hemopoiesis during thiamphenicol treatment. II. A theoretical analysis shows consistency of new new data with a previously hypothesized model of stem cell regulation.
    Exp. Hematol. 17 (1989) 962-967

    PDF Download (924 kB)

  • LOEFFLER, M.; PANTEL,K.; WULFF,H.; WICHMANN,H.E.
    A mathematical model of erythropoiesis in mice and rats.
    Part 1. Structure of the model.
    Cell Tissue Kinet. 22 (1989) 13-30

    PDF Download (1,3 MB)

  • WICHMANN,H.-E.; LOEFFLER, M.; PANTEL,K.; WULFF,H.
    A mathematical model of erythropoiesis in mice and rats.
    Part 2. Stimulated erythropoiesis.
    Cell Tissue Kinet. 22 (1989) 31-49

    PDF Download (757 kB)

  • WULFF,H.; WICHMANN,H..E.; LOEFFLER, M.; PANTEL,K.
    A mathematical model of erythropoiesis in mice and rats.
    Part 3. Suppressed erythropoiesis.
    Cell Tissue Kinet. 22 (1989) 51-61

    PDF Download (910 kB)

1990

  • PANTEL,K.; LOEFFLER, M.; BUNGART,B.; WICHMANN,H.E.
    A mathematical model of erythropoiesis in mice and rats.
    Part 4. Differences between bone marrow and spleen.
    Cell Tissue Kinet. 23 (1990) 283-297

    PDF Download (1,2 MB)

  • GORIS,H.; BUNGART,B.; LOEFFLER, M.; NIJHOF,W.
    Migration of stem cells and progenitors between marrow and spleen following a thiamphenicol treatment of mice.
    Exp. Hematol. 18 (1990) 400-407

    PDF Download (9,4 MB)

  • LOEFFLER, M.; PANTEL,K.
    A mathematical model of erythropoiesis suggests an altered plasma volume control as cause for anemia in aged mice.
    Exp. Gerontology 25 (1990) 483-495

    PDF Download (676 kB)

  • POTTEN,C.S.; LOEFFLER, M.
    Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.
    Development 110 (1990) 1001-1018
  • SCHMITZ,S.; LOEFFLER, M.; JONES,J.B.; LANGE,R.D.; WICHMANN,H.E.
    Synchrony of marrow maturation as origin of cyclic hemopoiesis.
    Cell Tissue Kinet. 23 (1990) 425-441

    PDF Download (616 kB)

  • MORRIS,G.M., VAN DEN AARDWEG,G.J.M.J., HAMLET,R., WHITEHOUSE,E., HOPEWELL,J.W., FRANKE,H., LOEFFLER, M.
    Age-related changes in the cell kinetics of rat epidermis
    Cell Tissue Kinet. 23 (1990) 113-123

    PDF Download (439 kB)

  • BUNGART,B.; LOEFFLER, M.; GORIS,H.; DONTJE,B.; DIEHL,V.; NIJHOF,W.
    Differential effects of rekombinant human colony stimulating factor (rh G-CSF) on stem cells in marrow, spleen and peripheral blood in mice.
    Br. J. Haematol. 76 (1990) 174-179

    PDF Download (286 kB)

1991

  • LOEFFLER, M.; GROSSMANN,B.
    A stochastic branching model with formation of subunits applied to the growth of intestinal crypts.
    J. Theoretical Biol. 150 (1991) 175-191

    PDF Download (1,3 MB)

1992

  • SCHEDING,S.; LOEFFLER, M.; SCHMITZ,S.; SEIDEL,H.J.; WICHMANN,H.E.
    Hematotoxic effects of benzene analyzed by mathematical modeling.
    Toxicology 72 (1992) 265-279

    PDF Download (588 kB)

  • SCHEDING,S.; LOEFFLER, M.; ANSELSETTER,V.; WICHMANN,H.E.
    A mathematical approach to benzo[a]pyrene-induced hematotoxicity.
    Arch Toxicology 66 (1992) 546-550

    PDF Download (362 kB)

  • PAULUS,U.; POTTEN,C.; LOEFFLER, M.
    A model of the control of cellular regeneration in the intestinal crypt after perturbation, based solely on local stem cell regulation.
    Cell Proliferation 25 (1992) 559-578

    PDF Download (969 kB)

1993

  • LOEFFLER, M.; BIRKE,A.; WINTON,D.; POTTEN,C.S.
    Somatic mutation, monoclonality and models of stem cell organization in the intestinal crypt.
    J. Theoretical Biol. 160 (1993) 471 - 491

    PDF Download (1,6 MB)

  • PAULUS, U.; LÖFFLER, M.; ZEIDLER,J.; OWEN,G.; POTTEN, C.S.
    The differentiation and lineage development of goblet cells in the murine small intestinal crypt: experimental and modelling studies.
    J. Cell Science 106 (1993) 473-484

    PDF Download (1,0 MB)

  • NIJHOF, W.; GORIS, H.; DONTJE, B.; DRESZ, J.; LOEFFLER, M.
    Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesis
    Experimental Hematology 21 (1993) 496 - 501

    PDF Download (359 kB)

1994

  • SCHMITZ, S.; FRANKE. H.; LOEFFLER, M.; WICHMANN, H.E.; DIEHL. V.
    Reduced variance of bone-marrow transit time of granulopoiesis - a possible pathomechanism of human cyclic neutropenia.
    Cell Prolif. 27 (1994) 655-667

    PDF Download (1,2 MB, Englisch)

  • LI., Y.Q.; ROBERTS,S.A.; PAULUS, U.; LOEFFLER, M.; POTTEN, C.S.
    The crypt cycle in mouse small intestinal epthelium.
    Journal of Cell Science 107 (1994) 3271-3279

    PDF Download (1,4 MB, Englisch)

  • DE HAAN, G.; ENGEL, CH; DONTJE, B.; NIJHOF,W.; LOEFFLER, M.
    Mutual inhibition of murine erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colony-stimulating factor and stem cell factor adminstration: In vivo interactions and dose response surfaces.
    Blood 12 Vol 84 (1994) 4157-4163

    PDF Download (810 kB, Englisch)

1995

  • DE HAAN, G.; DONTJE, B.; NIJHOF,W.; LOEFFLER, M.
    Effects of Continuous Stem Cell Factor Administration on Normal and Erythropoietin- Stimulated Murine Hemopoiesis. Experimental Results and Model Analysis.
    Stem Cells (Dayt) 13 (1995) 65-76

    PDF Download (1,3 MB, Englisch)

  • DE HAAN, G.; ENGEL, C.; DONTJE, B.; LOEFFLER, M.; NIJHOF, W.
    Hematoxicity by prolonged etoposide adminstration to mice can be prevented by simultaneous growth factor therapy.
    Cancer Research 55 (1995) 324-329

    PDF Download (756 kB, Englisch)

  • DE HAAN, G.; DONTJE, B.; ENGEL, C.; LOEFFLER, M.; NIJHOF, W.
    The kinetics of murine hemopoietic stem cells in vivo in response to prolonged increased mature blood cell production, induced by granulocyte colony-stimulating factor.
    Blood 86: 8 (1995) 2986-2992

    PDF Download (711 kB, Englisch)

  • DE HAAN, G.; DONTJE, B.; ENGEL, CH.; LOEFFLER, M.; NIJHOF, W.
    In vivo effects of interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis.
    British Journal of Hematology (1995) 90: 4, 783-790

    PDF Download (942 kB, Englisch)

1996

  • SCHMITZ S., FRANKE H., LOEFFLER M., WICHMANN H.E., DIEHL V.
    Model analysis of the contrasting effects of GM-CSF and G-CSF treatment on peripheral blood neutrophils observed in three patients with childhood-onset cyclic neutropenia.
    British Journal of Hematology 95: 4 (1996) 616-625

    PDF Download (714 kB, Englisch)

  • HASENCLEVER D., LOEFFLER M., Diehl V. for the German Hodgkin's Lymphoma Study Group
    Rationale for dose escalation of first line conventional chemotherapy in advanced Hodgkin's disease.
    Annals of Oncology 7: 4 (1996) 95-98

    PDF Download (445 kB, Englisch)

1998

  • LOEFFLER M., TSODIKOV A.D., YAKOVLEV A.YU.
    A cure model with time-changing risk factor: An application to the analysis of secondary leukemia.
    Statistics in Medicine 17 (1998) 27-40
  • ROEDER I., DE HAAN G., ENGEL C., NIJHOF W., DONTJE B., LOEFFLER M.
    Interactions of Erythropoietin, Granulocyte Colony-Stimulating Factor, Stem Cell Factor, and Interleukin-11 on Murine Hematopoiesis During Simultaneous Administration
    Blood 91: 9 (1998) 3222-3229

    PDF Download (1,8 MB, Englisch)

  • GERIKE T.G., PAULUS U., POTTEN C.S., LOEFFLER M.
    A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.
    Cell Proliferation 31, (1998) 93-110

    PDF Download (1,5 MB, Englisch)

  • TSODIKOV A.D., HASENCLEVER D., LOEFFLER M.
    Regression with bounted outcome score: Evaluation of power by bootstrap and simulation in a chronic myelogenous leukemia clinical trial
    Statistics in Medicine 17 (1998) 1909-1922

    PDF Download (1006 kB, Englisch)

  • LOEFFLER M., HASENCLEVER D., DIEHL V. for the German Hodgkin's Lymphoma Study Group
    Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease.
    Annals of Oncology 9 (1998) 5: 73-78

    PDF Download (573 kB, Englisch)

1999

  • ENGEL C., LOEFFLER M., FRANKE H., SCHMITZ ST.
    Endogenous thrombopoietin serum levels during multicycle chemotherapy
    British Journal of Haematology (1999) 105, 832-838

    PDF Download (431 kB, Englisch)

2000

  • POTTEN C. S., BARTHEL D., LI Y. Q., OHLRICH R., MATTHÉ B., LOEFFLER M.
    Proliferation in murine epidermis after minor mechanical stimulation - Part 1: Sustained increase in keranocyte production and migration.
    Cell Proliferation 33, 231-246 (2000)

    PDF Download (253 kB, Englisch, 16 Seiten)

  • BARTHEL D., MATTHÉ B., POTTEN C. S., OWEN G., LOEFFLER M.
    Proliferation in murine epidermis after minor mechanical stimulation - Part 2: Alterations in keranocyte cell cycle fluxes.
    Cell Proliferation 33, 247-259 (2000)

    PDF Download (146 kB, Englisch, 13 Seiten)

2001

  • DRASDO D., LOEFFLER, M.
    Individual-based models to growth and folding in lne-layered tissues: Intestinal cryps and early development
    Nonlinear Analysis 47 (2001) 245-256

    PDF Download (590 kB, Englisch, 12 Seiten)

  • MEINEKE F.A., POTTEN C.S., LOEFFLER, M.
    Cell migration and organization in the intestinal crypt using a lattice-free model
    Cell Proliferation 34, 253-266 (2001)

    PDF Download (834 kB, Englisch, 14 Seiten)

  • HASENCLEVER D., BROSTEANU O., GERIKE T., LOEFFLER M.
    Modelling of chemotherapy: The effective dose approach
    Ann. Hematol. 80: B89-B94 (2001)

    PDF Download (58 kB, Englisch, 6 Seiten)

2002

  • LOEFFLER M., ROEDER I.
    Tissue Stem Cells: definition, plasticity, heterogeneity, self organization and models - a conceptual approach.
    Cells Tissues Organs 171 (1) 8-26 (2002)

    PDF Download (354 kB, Englisch, 19 Seiten)

  • ROEDER I., LOEFFLER M.
    A Novel Dynamic Model of Hematopoietic Stem Cell Organization Based on the Concept of Within-Tissue Plasticity
    Experimental Hematology 30 (8), 853-861 (2002)

    PDF Download (471 kB, Englisch, 9 Seiten)

  • C.S. POTTEN, D. BOOTH, N.J. CRAGG, G.L. TUDOR, J.A. O'SHEA, D. APPLETON, D. BARTHEL, T. GERIKE, F. MEINEKE, M. LOEFFLER, C. BOOTH
    Cell kinetic studies in the murine ventral tongue epithelium: thymidine metabolism studies and circadian rhythm determination
    Cell Proliferation 35 (S1) 1-15 (2002)

    PDF Download (319 kB, Englisch, 15 Seiten)

  • LOEFFLER M.
    Modelling the effects of continuous irradiation on murine haematopoiesis.
    British Journal of Radiology (S26) 188-197 (2002)

    PDF Download (477 kB, Englisch, 10 Seiten)

2003

2004

  • H. BINDER, T. KIRSTEN, I. L. HOFACKER, P. F. STADLER, M. LOEFFLER
    Interactions in Oligonucleotide Hybrid Duplexes on Microarrays
    J. Phys. Chem. B 108 (46) 18015 - 18025 (2004)

    PDF Download (491 kB, Englisch, 11 Seiten)

  • H. BINDER, T. KIRSTEN, M. LOEFFLER, P.F. STADLER
    Sensitivity of Microarray Oligonucleotide Probes: Variability and the Effect of Base Composition
    J. Phys. Chem. B 108 (46) 18003-18014 (2004)

    PDF Download (919 kB, Englisch, 12 Seiten)

  • C. ENGEL, M. SCHOLZ, M. LOEFFLER
    A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy
    BLOOD 104 (8) 2323-2331 (2004)

    PDF Download (343 kB, Englisch, 9 Seiten)

  • M. LOEFFLER AND I. ROEDER
    Conceptual models to understand tissue stem cell organization
    Current Opinion in Hematology 11; 81-87 (2004)

    PDF Download (870 kB, Englisch, 7 Seiten)

  • M. SCHOLZ, C. ENGEL, M. LOEFFLER
    Modelling Human Granulopoiesis under Polychemotherapy with G-CSF Support
    Journal of Mathematical Biology 10.1007 285 - 295 (2004)

    PDF Download (769 kB, Englisch, 43 Seiten)

  • E.Schuster, S.Kropf, and I. Roeder
    Micro Array Based Gene Expression Analysis using Parametric Multivariate Tests per Gene - A Generalized Application of Multiple Procedures with Data-driven Order of Hypotheses
    Biometrical Journal 46(6): 687–698

    PDF Download (200 kB, Englisch, 12 Seiten)

2005

  • I. ROEDER, J. GALLE, M. LOEFFLER
    Theoretical concepts of tissue stem cell organization
    in print (2005)
  • Jörg Galle, Markus Loeffler, Dirk Drasdo
    Modeling the Effect of Deregulated Proliferation and Apoptosis on the Growth Dynamics of Epithelial Cell Populations in Vitro
    Biophysical Journal, 88, Pages 62-75 (2005)

    PDF Download (415 kB, Englisch)

  • I. Roeder, M. Kamminga, K. Braesel, B. Dontje, G. de Haan, M. LOEFFLER
    Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization
    Blood, 15 / 2, Pages 609 - 616 (2005)

    PDF Download (284 kB, Englisch, 8 Seiten)

  • K. Krohn, M. Eszlinger, R. Paschke, I. Roeder, and E. Schuster
    Increased power of microarray analysis by use of an algorithm based on a multivariate procedure
    Bioinformatics 21(17): 3530-4

    PDF Download (107 kB, Englisch, 5 Seiten)

2006

  • Markus Scholz, Christoph Engel, Markus Loeffler
    Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia
    British Journal of Haematology, 132, Pages 723-735 (2006)

    PDF Download (8,9 MB, Englisch)

  • I. Roeder and I. Glauche
    Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1
    J. Theor. Biol. (in press)

    PDF Download (410 kB, Englisch)

  • I. Roeder
    Quantitative stem cell biology - Computational studies in the hematopoietic system
    Curr. Opin. Hematol. 13(4):222-8

    PDF Download (178 kB, Englisch)